Spermicide Gel: What You Need to Know Conceive Plus The Pros and Cons of Spermicidal Lubricant External Condoms Understanding Spermicide: Health Education and Counseling Condoms protect against unplanned pregnancy and most sexually transmitted infections, including HIV, gonorrhoea, chlamydia, and syphilis. Use only water or silicone based lubricant with a condom during vaginal and particularly anal sex.